Three dozen chapters contribute to researchers' understanding of the molecular mechanisms involved in the breakdown of the blood-brain barrier (BBB) in brain disorders caused by stroke, trauma, inflammation, and tumors. In sections on tissue and permeability techniques, Nag (neuropathology, U. of Toronto) introduces the properties of cellular components of normal cerebral vessels and the pathophysiology of BBB breakdown. Other contributors provide step-by- step instructions on BBB transport, in vitro, molecular, and genomic methods, and discuss genetically altered models.