"At a Glance - HDL The good, but complex, cholesterol." (English Edition)

Epidemiological studies clearly show that levels of high-density lipoprotein cholesterol (HDL-C) are inversely associated with the risk of coronary artery disease and its thrombotic complications.
However, in a recent study, researchers tested the hypothesis that increased plasma HDL-C is protective for myocardial infarction (MI) by examining the relationship between genetic variations associated with elevated levels of plasma HDL-C and the risk of MI.
The major approach used is Mendelian randomization, a method developed to infer disease causality of a genetic variation.
An attempt has been made to include, in this Booklet, several evidence-based research works done by leading researchers, as recently, they have challenged this assumption by showing that genetically elevated HDL-C did not protect against myocardial infarction.
This finding has fueled a lively discussion in the lay, scientific, and medical press about the relationship between HDL-C and HDL function, and the potential effectiveness of various HDL-C raising strategies.

.........Dr.H.K.Saboowala

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