Two years have passed since elite police officer Damien Tomasso (Cyril Raffaelli) teamed up with reformed vigilante Leito (David Belle) to save the notorious District 13, a racially charged ghetto populated by violent drug dealing gangs and vicious killers. Despite government promises to maintain order, the state of the district has deteriorated and is causing civil unrest. A group of corrupt cops and elected officials conspire to cash in on the redevelopment of the district by proposing its destruction under the nuclear air strike. Damien and Leito must join forces again, using their martial arts and unique physical skills, to bring peace to the neighborhood by any means necessary.